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Brimonidine-induced anterior uveitis and conjunctivitis: clinical and histologic features
Ethan V Nguyen1, Domit Azar, Daya Papalkar
1Royal Prince Alfred Hospital, Camperdown, Sydney, New South Wales, Australia. ethannguyen1983@yahoo.com
Abstract:
Brimonidine tartarate is a selective alpha2-adrenergic receptor agonist that is indicated for use in the treatment of glaucoma and ocular hypertension. Since its introduction in 1997 there have been a small number of case reports concerning granulomatous anterior uveitis as a late adverse reaction to long-term brimonidine therapy. We report a case of bilateral anterior uveitis and granulomatous papillary conjunctivitis in a 78-year-old gentleman after 2 years of brimonidine therapy. Cessation of brimonidine lead to rapid termination of uveitis. The histologic features of the conjunctiva are described. This has not been previously reported.
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