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Updated: Jul 7, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Novel concepts in androgen receptor blockade.
Andrew C Hsieh1, Charles J Ryan
1The Urologic Oncology Program, UCSF Comprehensive Cancer Center, University of California-San Francisco, San Francisco, CA 94143, USA.
Maximal blockade of androgen receptor signaling is crucial for treating advanced prostate cancer. This review explores new therapeutic strategies targeting androgen receptor signaling in castration-resistant prostate cancer.
Area of Science:
- Oncology
- Urology
- Molecular Biology
Background:
- Androgen receptor (AR) blockade is a primary treatment for prostate cancer.
- AR signaling persists and drives disease progression even at castrate testosterone levels.
- Castration-resistant prostate cancer (CRPC) necessitates advanced therapeutic strategies.
Purpose of the Study:
- To review current therapeutic developments targeting AR signaling in CRPC.
- To highlight novel approaches for maximal AR blockade in prostate cancer management.
Main Methods:
- Review of existing literature and ongoing research on AR signaling pathways.
- Analysis of therapeutic strategies including direct AR inhibitors, adrenal androgen synthesis inhibitors, and dual 5alpha-reductase isoenzyme inhibitors.
Main Results:
- Several therapeutic avenues are being explored to inhibit AR signaling in CRPC.
- Targeting AR directly, adrenal androgen synthesis, and specific enzymes shows promise.
Conclusions:
- Continued research into AR signaling inhibition is vital for improving CRPC outcomes.
- Combination therapies targeting multiple aspects of AR signaling may offer enhanced efficacy.
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