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08:45
Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
Published on: July 17, 2020
Protein tyrosine phosphatases in autoimmunity
Torkel Vang1, Ana V Miletic, Yutaka Arimura
1Burnham Institute for Medical Research, La Jolla, California 92037, USA. tvang@burnham.org
Annual Review of Immunology
|February 29, 2008
Summary
Protein tyrosine phosphatases (PTPs) regulate cellular functions and are linked to human diseases. This review highlights PTPs
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Background:
- Protein tyrosine phosphatases (PTPs) are crucial regulators of diverse cellular processes.
- Dysregulation of PTPs is increasingly associated with various human pathologies, including developmental defects, cancer, and immunodeficiency.
- The role of PTPs in autoimmune diseases is an area of active investigation.
Purpose of the Study:
- To review the involvement of PTPs in human autoimmune diseases.
- To discuss specific PTPs implicated in autoimmunity, such as PTPN22 and PTPRC.
- To explore the potential of PTPs as therapeutic targets for immune system regulation.
Main Methods:
- Literature review of scientific publications on PTPs and autoimmunity.
- Analysis of genetic associations between PTP variants and autoimmune conditions.
- Discussion of molecular mechanisms underlying PTP involvement in immune responses.
Main Results:
- The lymphoid tyrosine phosphatase (PTPN22) allelic variant is strongly associated with multiple autoimmune diseases.
- Mutations affecting CD45 (PTPRC) splicing are implicated in autoimmune disorders.
- Evidence suggests additional PTPs contribute to susceptibility to autoimmune and inflammatory diseases.
Conclusions:
- PTPs play a significant role in the pathogenesis of human autoimmunity.
- Specific PTPs, like PTPN22 and PTPRC, are key players in immune system regulation and disease.
- Targeting PTPs involved in immune regulation offers a promising therapeutic strategy for autoimmune diseases.
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