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03:05
Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
[Nonbacterial thrombotic endocarditis and gastric carcinoma]
S Dupeux1, L Bricaire, A Bosquet
1Service de médecine interne, hôpital Européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France. sidonie.dupeux@egp.aphp.fr
La Revue De Medecine Interne
|February 29, 2008
Summary
Nonbacterial thrombotic endocarditis, a rare condition, can manifest with heart failure and stroke in gastric adenocarcinoma patients. Early diagnosis and anticoagulation are crucial for managing this thrombotic complication.
Area of Science:
- Cardiology
- Oncology
- Hematology
Background:
- Nonbacterial thrombotic endocarditis (NBTE) is a rare condition often associated with malignancy.
- NBTE involves the formation of sterile thrombi on heart valves, leading to embolic events.
- Gastric adenocarcinoma is an uncommon but recognized cause of NBTE.
Observation:
- A 74-year-old woman presented with acute heart failure and recurrent ischemic strokes.
- These symptoms were attributed to nonbacterial thrombotic endocarditis.
- The NBTE was complicating an underlying gastric adenocarcinoma.
Findings:
- Diagnosis of NBTE is challenging and rarely achieved antemortem.
- Coagulation abnormalities secondary to the gastric tumor were identified as the cause of valvular thrombosis.
- Heparin anticoagulation provided only a few months of remission.
Implications:
- This case highlights the importance of considering NBTE in cancer patients with embolic events.
- Early diagnosis and management of NBTE are critical for improving patient outcomes.
- The role of anticoagulation in NBTE is supported, while surgical intervention remains debated.
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