Lymphadenopathy caused by Mycobacterium colombiense
Oscar Esparcia1, Ferran Navarro, Miquel Quer
1Servei de Microbiologia, Hospital de la Santa Creu i Sant Pau, Av. Sant Antoni M Claret, 167, 08025 Barcelona, Spain.
Journal of Clinical Microbiology
|February 29, 2008
Summary
A 3-year-old girl was diagnosed with lymphadenopathy due to Mycobacterium colombiense, a recently identified species. This slow-growing bacterium, part of the Mycobacterium avium complex, was identified using 16S rRNA gene sequencing.
Area of Science:
- Microbiology
- Infectious Diseases
- Genetics
Background:
- The Mycobacterium avium complex (MAC) comprises several species, some of which are opportunistic pathogens.
- Accurate identification of MAC species is crucial for appropriate patient management and understanding disease epidemiology.
- Lymphadenopathy is a common presentation of mycobacterial infections, particularly in children.
Observation:
- A 3-year-old girl presented with cervical lymphadenopathy.
- Initial investigations suggested a mycobacterial etiology.
- The causative agent was identified as a novel species, Mycobacterium colombiense.
Findings:
- Mycobacterium colombiense was identified as the cause of lymphadenopathy in this pediatric case.
- This species is characterized as a nonpigmented, slow-growing bacterium.
- Partial sequencing of the 16S rRNA gene confirmed the species identification, distinguishing it from other MAC members.
Implications:
- This case highlights Mycobacterium colombiense as a potential pathogen causing lymphadenopathy in children.
- The findings underscore the importance of molecular methods, such as 16S rRNA sequencing, for accurate mycobacterial speciation.
- Further research is needed to define the full spectrum of diseases caused by Mycobacterium colombiense and its prevalence.
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