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Published on: December 16, 2022
Correlation between denial of illness and executive function following stroke: a pilot study
Kenji Narushima1, David J Moser, Robert G Robinson
1Department of Psychiatry, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, 200 Hawkins Dr., 2887 JPP, IA City, IA 52246, USA.
The Journal of Neuropsychiatry and Clinical Neurosciences
|February 29, 2008
Summary
Antidepressant treatment after stroke improved executive function and reduced illness denial. These cognitive improvements were linked to a decreased denial of illness over two years.
Area of Science:
- Neuroscience
- Psychiatry
- Rehabilitation Medicine
Background:
- Stroke frequently results in executive dysfunction and denial of illness, impacting patient recovery and adherence.
- Antidepressant medications are often used to manage post-stroke mood disorders, but their effects on cognitive function and denial require further investigation.
Purpose of the Study:
- To investigate the relationship between executive function and denial of illness in stroke patients undergoing antidepressant treatment.
- To assess changes in executive function and denial of illness from 3 months to 2 years post-treatment.
Main Methods:
- A double-blind study involving 24 patients treated with antidepressants post-stroke.
- Assessment of executive function and denial of illness at 3 months (end-of-treatment) and 2-year follow-up.
Main Results:
- A significant correlation was observed between improvements in executive function and a decrease in the denial of illness.
- The study identified a link between enhanced cognitive abilities and a reduced tendency to deny illness in the long term.
Conclusions:
- Antidepressant treatment following stroke may positively influence executive function.
- Improved executive function is associated with a reduction in denial of illness in stroke survivors, suggesting a potential therapeutic target.
