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[Adjuvant chemotherapy].

A Del Nero1, A Mandressi, G Longo

  • 1Istituto di Urologia, Università di Milano.

Archivio Italiano Di Urologia, Nefrologia, Andrologia : Organo Ufficiale Dell'Associazione Per La Ricerca in Urologia = Urological, Nephrological, and Andrological Sciences
|June 1, 1991
PubMed
Summary
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Continuous infusion of 5-Fluoro 2-Deoxyuridine (FUDR) showed minimal toxicity and high efficacy in advanced renal cell carcinoma patients. This outpatient therapy offers a normal quality of life with convenient drug delivery.

Area of Science:

  • Oncology
  • Pharmacology
  • Medical Devices

Context:

  • Advanced renal cell carcinoma (RCC) presents significant treatment challenges.
  • Continuous infusion chemotherapy requires reliable and convenient drug delivery systems.
  • Evaluating novel administration methods for established chemotherapeutic agents is crucial for improving patient outcomes.

Purpose:

  • To assess the safety, efficacy, and feasibility of continuous venous infusion of 5-Fluoro 2-Deoxyuridine (FUDR) in advanced renal cell carcinoma patients.
  • To evaluate the use of an implantable pump for FUDR delivery in an outpatient setting.
  • To determine the toxicity profile and quality of life associated with this FUDR administration method.

Summary:

  • Ten patients with advanced renal cell carcinoma received 14-day cycles of 5-Fluoro 2-Deoxyuridine (FUDR) via continuous central venous infusion using an implantable pump, alternating with saline.

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  • Over a median observation period of 22.1 months (range: 8-32 months), only one patient experienced disease progression.
  • The treatment demonstrated minimal toxicity, was safely and conveniently administered in an outpatient setting, and was associated with a normal quality of life.

    • Impact:

    • Circadian continuous central venous infusion of FUDR represents a safe and effective treatment option for advanced renal cell carcinoma.
    • The use of implantable pumps facilitates long-term, convenient chemotherapy administration, improving patient compliance and quality of life.
    • This approach offers a minimally toxic and well-tolerated therapeutic strategy for patients with advanced RCC, potentially improving long-term management.