Related Experiment Videos
[Platelets and migraine. Correlation between biochemical markers of platelet aggregation and serotonin]
R Leira1, J Castillo, F Martínez
1Servicio de Neurología, Hospital General de Galicia Clínico Universitario, Santiago de Compostela, La Coruña.
Neurologia (Barcelona, Spain)
|January 1, 1991
Abstract:
The correlation between the biochemical markers of platelet activation and serotonin in migraine was investigated. The beta-thromboglobulin (beta-TG), platelet factor 4 (PF-4) and serotonin levels in 105 patients with migraine were measured. The results confirmed an increase in beta-TG and PF4 levels and a reduction in serotonin levels during the migraine attacks. However, we did not find a significant correlation between these fluctuations. These findings suggest the existence of extraplatelet mechanism in the pathophysiology of migraine.