[The experience of initiating the projects in ophthalmologic research]

The choice of subjects plays a significant role in scientific research. About how to make a good choice, author's brief experience is to keep one theme, two essentials, three thinking and four methods. One theme refers to innovation. The headspring of innovation is associative thinking, which bases on extensive knowledge and excellent summing-up. Two essentials refer to the essential of being steadfast and earnest and the essential of "nail" which stands for persistence. Three thinking refer to associative thinking, logical thinking and converse thinking. Four methods refer to method of reading, method of practice, method of consultation and method of inversion.