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Xanthogranulomatous pyelonephritis: clinical experience with 41 cases
Fernando Korkes1, Ricardo L Favoretto, Marcos Bróglio
1Division of Urology, Faculty of Medical Sciences of Santa Casa de São Paulo, São Paulo City, São Paulo, Brazil. fkorkes@terra.com.br
Urology
|March 1, 2008
Summary
Xanthogranulomatous pyelonephritis (XGP) is a common variant of surgically managed pyelonephritis, often seen in middle-aged women. This study highlights its clinical presentation, radiologic findings, and association with renal calculi.
Area of Science:
- Nephrology
- Urology
- Pathology
Background:
- Xanthogranulomatous pyelonephritis (XGP) is an uncommon inflammation of the renal parenchyma.
- It typically occurs with chronic obstruction and suppuration.
Purpose of the Study:
- To review the features of 41 recent cases of XGP.
- To compare these findings with current published data.
Main Methods:
- Retrospective evaluation of clinical, surgical, and radiologic features of 41 XGP cases.
- Comparison of Brazilian population data with published reports.
Main Results:
- XGP accounted for 19.2% of nephrectomies for pyelonephritis.
- 85.4% of patients were women; common symptoms included fever, pain, and weight loss.
- CT findings showed hydronephrosis, kidney enlargement, and poor contrast excretion; all patients had renal calculi.
Conclusions:
- XGP is a common histologic variant of surgically managed pyelonephritis.
- The study population comprised mostly middle-aged women with pain and constitutional symptoms.
- Computed tomography is the preferred imaging modality for diagnosing XGP.
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