Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

It's not all about nephrin.

M Simons1, T B Huber

  • 1Mount Sinai School of Medicine, Department of Developmental and Regenerative Biology, New York, New York 10029, USA. matias.simons@mssm.edu

Kidney International
|March 1, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preoperative LVSI assessment in early-stage cervical cancer: Can it reliably guide lymph node management?

Gynecologic oncology·2026
Same author

Successful Pregnancy Management of a Woman With Severe Methylmalonic Acidemia.

JIMD reports·2025
Same author

Thermal asymmetry in the Moon's mantle inferred from monthly tidal response.

Nature·2025
Same author

Author Correction: Syndecan-2 selectively regulates VEGF-induced vascular permeability.

Nature cardiovascular research·2024
Same author

Stability of a Novel PEGylation Site on a Putative Haemoglobin-Based Oxygen Carrier.

Advances in experimental medicine and biology·2022
Same author

Syndecan-2 selectively regulates VEGF-induced vascular permeability.

Nature cardiovascular research·2022
Same journal

KDIGO Life Cycle of Guideline Development Series Part 6: Bridging the Gap between Guidelines and Clinical Practice: The KDIGO Approach to Global Implementation and Education in Nephrology.

Kidney international·2026
Same journal

KDIGO Life Cycle of Guideline Development Series Part 5: Guideline updates and a living model for the future.

Kidney international·2026
Same journal

Crystal-Storing Histiocytosis Causing Severe AKI.

Kidney international·2026
Same journal

Peritoneal dialysis in a patient with extensive burn scarring.

Kidney international·2026
Same journal

COPA syndrome unmasked by anti-neutrophil cytoplasmic antibody-positive immune-complex nephritis.

Kidney international·2026
Same journal

Monitoring anti-nephrin antibodies in the management of recurrent diffuse podocytopathy.

Kidney international·2026
See all related articles

Mutations in the NPHS1 gene cause Finnish nephrotic syndrome. A new study shows that while the absence of nephrin disrupts slit diaphragms, it does not impact podocyte survival or gene expression.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Genetics

Background:

  • Congenital nephrotic syndrome of the Finnish type is caused by mutations in the NPHS1 gene.
  • Nephrin, the NPHS1 gene product, is a key structural component of the glomerular slit diaphragm in podocytes.
  • Nephrin has been implicated in signaling pathways crucial for podocyte survival and differentiation.

Discussion:

  • The study investigates the functional consequences of nephrin absence in podocytes.
  • It examines the impact on slit diaphragm formation, podocyte apoptosis, and gene expression.
  • Findings challenge the notion that nephrin is essential for podocyte survival signaling.

Key Insights:

  • Absence of nephrin results in the complete lack of glomerular slit diaphragms.

Related Experiment Videos

  • Podocyte apoptosis is not increased in nephrin-deficient models.
  • Podocyte gene expression patterns remain largely unaffected by the lack of nephrin.

    • Outlook:

    • Further research is needed to fully elucidate the signaling roles of nephrin beyond its structural function.
    • Understanding these pathways could reveal new therapeutic targets for nephrotic syndromes.
    • Investigating compensatory mechanisms in podocytes lacking nephrin may offer insights into kidney resilience.