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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Reagent-controlled domino synthesis of skeletally-diverse compound collections
Herbert Waldmann1, Marc Kühn, Wei Liu
1Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany. Herbert.Waldmann@mpi-dortmund.mpg.de
Abstract:
An efficient reagent-controlled methodology for generating highly substituted diverse scaffolds from a common substrate has been developed; thus, treatment of a common precursor with different desilylating reagents, such as ammonium fluoride, caesium fluoride and PPTS, triggers different domino reaction sequences, yielding highly substituted pyridines, phenols and benzopyrans, respectively; the substituent patterns of these scaffolds provide further opportunities for library development.
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