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Updated: Jul 7, 2026
11:47
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
[Trends in osteoporosis]
1Service des maladies osseuses, Centre collaborateur de l'OMS pour la prévention de l'ostéoporose Département de réhabilitation et gériatrie, HUG, 1211 Genève. Brigitte.Uebelhart@hcuge.ch
Revue Medicale Suisse
|March 4, 2008
Summary
New osteoporosis treatments include monoclonal antibodies targeting cathepsin-K, Rank-ligand, or sclerostin. Current options like zoledronate and risedronate offer fracture risk reduction, with rare side effects like osteonecrosis of the jaw.
Area of Science:
- Bone biology and osteoporosis research.
- Pharmacological interventions for bone diseases.
Context:
- Osteoporosis management involves various therapeutic agents.
- Bisphosphonates (zoledronate, risedronate) and selective estrogen receptor modulators (raloxifene, basedoxifene) are established treatments.
- Emerging biologic therapies offer new avenues for osteoporosis treatment.
Purpose:
- To review current and emerging therapeutic strategies for osteoporosis.
- To discuss the efficacy and safety of various osteoporosis medications.
- To highlight the need for improved patient adherence to osteoporosis treatment.
Summary:
- Monoclonal antibodies targeting cathepsin-K, Rank-ligand, or sclerostin represent future osteoporosis therapies.
- Zoledronate and risedronate demonstrate significant fracture risk reduction with favorable safety profiles, including low rates of osteonecrosis of the jaw.
- Basedoxifene shows efficacy in reducing vertebral fractures, similar to raloxifene.
Impact:
- Provides an overview of current and novel osteoporosis treatments.
- Informs clinicians about the efficacy, safety, and administration of osteoporosis medications.
- Emphasizes the critical need for strategies to enhance patient treatment adherence in osteoporosis management.
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