Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 7, 2026

Appetitive Associative Olfactory Learning in Drosophila Larvae
09:22

Appetitive Associative Olfactory Learning in Drosophila Larvae

Published on: February 18, 2013

Visual pattern memory requires foraging function in the central complex of Drosophila.

Zhipeng Wang1, Yufeng Pan, Weizhe Li

  • 1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

Learning & Memory (Cold Spring Harbor, N.Y.)
|March 4, 2008
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual Electric Fields in Cyclooctatetrathiophene-Based COF/ ZnIn<sub>2</sub>S<sub>4</sub> Z-Scheme Heterojunction Boost Photocatalytic Seawater Hydrogen Evolution.

Angewandte Chemie (International ed. in English)·2025
Same author

Measuring the Nursing Work Environment during Public Health Emergencies: Scale Adaptation and Validation.

Journal of nursing management·2025
Same author

Three-Dimensional Covalent Organic Frameworks with jcg Topology Based on a Trinodal Strategy.

Journal of the American Chemical Society·2025
Same author

Synthesis of three-dimensional covalent organic frameworks through a symmetry reduction strategy.

Nature chemistry·2025
Same author

Morphological Tuning of Covalent Organic Framework Single Crystals.

Journal of the American Chemical Society·2024
Same author

Development and psychometric testing of the nurses' core competencies for public health emergencies scale: A multicenter cross-sectional study.

Nurse education today·2024

The foraging (for) gene, encoding cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase (PKG), is crucial for visual learning in Drosophila. Lower PKG levels impair memory, but gene expression in specific brain regions rescues this defect.

Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Molecular Biology

Background:

  • The foraging (for) gene, encoding cyclic guanosine-3",5"-monophosphate (cGMP)-dependent protein kinase (PKG), is known for its role in Drosophila food-search behavior.
  • Its involvement in other complex behaviors, particularly learning and memory, remains less understood.

Purpose of the Study:

  • To investigate the role of the for gene and its encoded PKG in operant visual learning and memory in Drosophila.
  • To identify the specific neural circuits within the Drosophila brain that mediate for-dependent visual pattern memory.

Main Methods:

  • Utilized natural variants of Drosophila melanogaster with differing PKG levels (rover (for(R)) and sitter (for(S))).
  • Employed genetic manipulation techniques, including constitutive and adult-limited expression of the for gene in specific brain regions (fan-shaped body and ellipsoid body).

More Related Videos

In Vivo Imaging of Neural Activity in Unanesthetized Drosophila Adult Flies
09:15

In Vivo Imaging of Neural Activity in Unanesthetized Drosophila Adult Flies

Published on: June 20, 2025

In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster
06:35

In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster

Published on: October 8, 2019

Related Experiment Videos

Last Updated: Jul 7, 2026

Appetitive Associative Olfactory Learning in Drosophila Larvae
09:22

Appetitive Associative Olfactory Learning in Drosophila Larvae

Published on: February 18, 2013

In Vivo Imaging of Neural Activity in Unanesthetized Drosophila Adult Flies
09:15

In Vivo Imaging of Neural Activity in Unanesthetized Drosophila Adult Flies

Published on: June 20, 2025

In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster
06:35

In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster

Published on: October 8, 2019

  • Assessed visual pattern memory performance in genetically modified flies using an operant visual learning paradigm.

    • Main Results:

    • Drosophila with lower PKG levels (for(S) variant) exhibited impaired visual pattern memory compared to for(R) flies.
    • Restoring for gene expression in the fan-shaped body or ellipsoid body rescued the memory defects in for(S) flies.
    • Specific expression patterns of for in the fan-shaped body and ellipsoid body differentially affected memory for distinct visual parameters (elevation vs. contour orientation).

    Conclusions:

    • The for gene and cGMP-PKG signaling are essential for associative learning and memory in Drosophila.
    • The fan-shaped body and ellipsoid body are key neural circuits involved in for-dependent visual pattern memory.
    • This study establishes a valuable Drosophila model for dissecting the molecular and neural mechanisms underlying learning and memory.