Related Experiment Video
Updated: Jul 7, 2026

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
Published on: September 23, 2022
Vaccination coverage in children can be estimated from health insurance data
Helen Kalies1, Rebekka Redel, Rudolf Varga
1Institute for Social Paediatrics and Adolescent Medicine, Munich, Germany. kalies@uni-muenchen.de
Insights
Statutory health insurance billing data can effectively monitor childhood vaccination coverage. Adjustments for denominator challenges ensure reliable immunisation estimates for public health.
Area of Science:
- Public Health
- Epidemiology
- Health Services Research
Background:
- Assessing vaccination coverage in young children is crucial for public health surveillance.
- New vaccines necessitate rapid and reliable methods for monitoring uptake.
- Statutory health insurance (SHI) data offers a potential source for timely vaccination coverage assessment.
Purpose of the Study:
- To evaluate the utility of routine data from statutory health insurances (SHI) for monitoring childhood vaccination coverage.
- To compare vaccination coverage estimates derived from SHI billing data with those from continuously insured children.
Main Methods:
- Utilized medical codes for childhood vaccinations from SHI billing data in Bavaria for children born between 2001-2002.
- Analyzed vaccine uptake up to 24 months of age.
- Compared coverage estimates from SHI billing data against a subset of continuously insured children.
Main Results:
- Defining an accurate denominator from billing data was challenging due to migration and insurance changes, inflating child counts.
- A refined dataset focusing on children with consistent insurance and physician visits yielded 111,977 children.
- Vaccination coverage estimates using SHI data were only slightly higher (max 1.7%) than those from continuously insured children.
Conclusions:
- Physician billing data, with appropriate denominator adjustments, is a viable tool for estimating immunisation coverage.
- Minor overestimation in coverage estimates can occur due to children not accessing healthcare services.
- SHI data provides a promising avenue for efficient and timely monitoring of childhood vaccination programs.
Background:
The introduction of new vaccines for young children requires instruments for a rapid and timely assessment of the progressively increasing vaccination coverage. We assessed whether routine data generated by statutory health insurances (SHI) might be used to monitor vaccination coverage in young children.
Methods:
For 90% of the population Germany's healthcare system is premium-funded through SHI. Specific medical codes on childhood vaccination are used for billing. These were used to analyse vaccine uptake up to 24 months in children born in Bavaria between 2001-10-01 and 2002-12-31. For children insured in the biggest SHI, vaccination coverage estimates based on billing data were compared to estimates considering only continuously insured children since birth, based on additional data provided by this SHI.
Results:
Definition of an appropriate denominator from the billing data was a major challenge: defining the denominator by any consultation by children with different ID numbers yielded 196,732 children, exceeding the number of births in Bavaria by a factor of 1.4. The main causes for this inflated denominator were migration and change of health insurance number. A reduced dataset based on at least one physician's visit in the first six months and 2nd year of life yielded 111,977 children. Vaccination coverage estimates for children in the biggest SHI were at maximum 1.7% higher than in the data set based on continuously insured children.
Conclusion:
With appropriate adjustments to define the denominator physician's billing data provide a promising tool to estimate immunisation coverage. A slight overestimation based on these data was explained by children never seeing a physician.
More Related Videos
Related Concept Videos
Vaccinations
Preventive Healthcare Services
Drug Dosing: Infants and Children
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Vaccines
Pharmacokinetics in Pediatric Patients: Drug Distribution

