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Updated: Jul 7, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Upregulation of PEDF expression by PARP inhibition contributes to the decrease in hyperglycemia-induced apoptosis in

Haibing Chen1, Weiping Jia, Xun Xu

  • 1Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Department of Endocrinology and Metabolism of Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.

Biochemical and Biophysical Research Communications
|March 4, 2008
PubMed
Summary

Poly(ADP-ribose)polymerase (PARP) inhibitors upregulate pigment epithelium-derived factor (PEDF) expression in endothelial cells. This suggests PEDF is a potential target for PARP inhibition therapies, influencing cell growth context-dependently.

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