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Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...

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Updated: Jul 7, 2026

Isolation of Chondrocytes and Chondroprogenitors Using Fibronectin Adhesion and Migratory Assay
08:09

Isolation of Chondrocytes and Chondroprogenitors Using Fibronectin Adhesion and Migratory Assay

Published on: October 4, 2024

Chondromyxoid fibroma.

Adam M Budny1, Ameera Ismail, Lawrence Osher

  • 1Nason Hospital, Roaring Spring, PA, USA. ABudnyDPM@gmail.com

The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons
|March 4, 2008
PubMed
Summary
This summary is machine-generated.

Chondromyxoid fibroma, a rare benign bone tumor, typically affects long bones. This case highlights an unusual, incidental finding in a first metatarsal bone associated with hallux abductovalgus.

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Area of Science:

  • Orthopedic Oncology
  • Skeletal Radiology
  • Pediatric Orthopedics

Background:

  • Chondromyxoid fibroma (CMF) is a rare, benign cartilaginous tumor, representing <1% of all bone neoplasms.
  • Typically, CMF affects the metaphyseal regions of long bones in the second to third decades of life.
  • Common symptoms include nonspecific pain and swelling at the affected site.

Observation:

  • This report details an incidental finding of a CMF.
  • The tumor was eccentrically located in the diaphysis of the first metatarsal.
  • The finding occurred in a patient with juvenile hallux abductovalgus deformity, with no preceding symptoms.

Findings:

  • The case presents an atypical location (diaphyseal first metatarsal) and presentation (incidental finding) of chondromyxoid fibroma.
  • This contrasts with the classic metaphyseal involvement and symptomatic presentation in younger adults.
  • The association with hallux abductovalgus deformity is noteworthy.

Implications:

  • Highlights the importance of considering rare bone tumors even in atypical locations.
  • Emphasizes the value of early detection and complete surgical resection for CMF to prevent recurrence.
  • Suggests potential, though unproven, associations between foot deformities and bone tumors.