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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Ventricular-vascular interaction in heart failure.
Barry A Borlaug1, David A Kass
1Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA. borlaug.barry@mayo.edu
Heart Failure Clinics
|March 4, 2008
Summary
Heart failure with preserved ejection fraction (HFpEF) affects nearly half of patients and is linked to stiffening of the ventricles and arteries. Understanding this pathophysiology may lead to new HFpEF treatments.
Area of Science:
- Cardiology
- Cardiovascular Physiology
Background:
- Heart failure with preserved ejection fraction (HFpEF) accounts for nearly 50% of heart failure cases.
- HFpEF patients are typically older, female, and hypertensive, exhibiting increased ventricular and arterial stiffness.
Purpose of the Study:
- To discuss the pathophysiology of abnormal ventriculoarterial stiffening in HFpEF.
- To explore the impact of stiffening on cardiac function, hemodynamics, and symptoms.
Main Methods:
- Review of the pathophysiology of ventriculoarterial stiffening.
- Discussion of its effects on cardiovascular system.
Main Results:
- Abnormal ventriculoarterial stiffening is a key feature of HFpEF.
- This stiffening impacts ventricular function, cardiovascular hemodynamics, and reduces reserve capacity, leading to symptoms.
Conclusions:
- Understanding the pathophysiology of ventriculoarterial stiffening is crucial for HFpEF.
- Novel therapeutic strategies targeting ventriculoarterial interaction may offer new treatment options for HFpEF.
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