Related Experiment Video
Updated: Jul 4, 2026

10:19
Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
Published on: August 22, 2014
Treadmill exercise testing in an epidemiologic study of elderly subjects.
M Hollenberg1, L H Ngo, D Turner
1Department of Medicine, University of California, San Francisco, USA. hollenberg.milton@sanfrancisco.va.gov
Summary
This study established exercise norms for older adults, finding that peak oxygen consumption declines with age but is influenced by body composition, not sex. Data provides insights into aging and fitness for community-dwelling seniors.
Area of Science:
- Gerontology
- Exercise Physiology
- Cardiovascular Health
Background:
- Understanding physical performance in aging populations is crucial for health and fitness.
- Establishing normative data for exercise responses in older adults is essential for clinical and research applications.
- Community-based studies provide valuable insights into the health of diverse aging populations.
Purpose of the Study:
- To characterize the physical performance of older subjects in a community-based study.
- To establish norms of oxygen consumption (VO2) during exercise in individuals aged 55-94.
- To investigate age and sex differences in exercise capacity and factors influencing them.
Main Methods:
- A community-based census identified 3057 individuals; 2092 participated.
- 1101 healthy subjects (55-94 years) underwent treadmill exercise testing using the Cornell protocol.
- Maximal exercise was defined by a respiratory exchange ratio (RER) ≥ 1.10; peak oxygen consumption (VO2) was measured.
Main Results:
- 73.8% of women and 89.5% of men achieved a minimal exercise workload (RER ≥ 1.00).
- 32.9% of women and 52.7% of men achieved maximal exercise (RER ≥ 1.10).
- Peak VO2/kg/min decreased linearly with age for both sexes; sex differences were explained by body composition (body fat percentage).
Conclusions:
- This study provides community-based data on exercise participation and maximal exercise achievement in older adults.
- Exercise duration, peak VO2, and heart rate declined with age.
- Sex differences in peak VO2 are largely attributable to differences in body fat percentage, not lean body mass.

