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Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Revisionist Views of Adolescent and Adult Cognition

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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Related Experiment Video

Updated: Jul 6, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

Toward a control theory analysis of aging.

Michael P Murphy1, Linda Partridge

  • 1Medical Research Council Dunn Human Nutrition Unit, Cambridge, United Kingdom. mpm@mrc-dunn.cam.ac.uk

Annual Review of Biochemistry
|March 6, 2008
PubMed
Summary

Aging results from accumulated damage, but identifying key contributing factors is challenging. This study proposes a hierarchical framework and metabolic control analysis to pinpoint critical aging processes for experimental investigation.

Area of Science:

  • Gerontology and Systems Biology
  • Investigating the biological processes underlying aging and organismal decline.

Background:

  • Aging is characterized by cumulative damage impacting organismal function and survival.
  • The relative importance of diverse aging processes remains difficult to ascertain.
  • Existing models often lack a clear framework for dissecting aging mechanisms.

Purpose of the Study:

  • To introduce a novel hierarchical framework for analyzing aging.
  • To adapt metabolic control analysis (MCA) for identifying critical aging factors.
  • To provide a method for understanding organismal decline from systems to cellular levels.

Main Methods:

  • Describing organismal function as interacting physiological systems.
  • Linking system output degradation to cellular changes (number, function).

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An Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing
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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Related Experiment Videos

Last Updated: Jul 6, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

An Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing
04:30

An Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing

Published on: October 25, 2019

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

  • Applying metabolic control analysis (MCA) within a hierarchical structure.

    • Main Results:

    • The proposed framework integrates organismal, cellular, and metabolic levels.
    • MCA methods are adapted to quantify the impact of specific changes on aging.
    • This approach offers a systematic way to evaluate the contribution of different factors to aging.

    Conclusions:

    • A hierarchical framework combined with MCA provides a powerful tool for aging research.
    • This methodology facilitates the identification of key determinants of aging.
    • The approach is valuable for both conceptualizing and experimentally analyzing aging processes.