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Published on: November 7, 2018
[Distribution of hepatitis B virus genotypes and its clinical significance]
1Handan Infections Disease Hospital, Handan 056002, China. konghb@163.com
Objective:
To study the distribution of hepatitis B virus genotypes in Handan area and clarify the genotype-related difference in clinic.
Methods:
Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to detect the HBV genotypes in 108 HBV-infected patients from Handan area. The clinical significance of HBV genotype was analyzed in combination with the values of HBV DNA and ALT.
Results:
Among the 108 HBV-infected patients, the proportion of genotype B and C was 6.5 percent and 93.5 percent, respectively. Genotype distribution showed no significant difference between male and female patients. ALT and AST levels were higher in genotype C group than those in genotype B group.
Conclusion:
HBV genotype C is predominant in chronic hepatitis B patients in Handan area. The positive rates of HBeAg and HBV DNA levels were higher in genotype C group than those in genotype B group. Genotype C was associated with the development of severe liver disease as compared to genotype B.
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