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Updated: Jul 6, 2026
10:54
Extraction of Plant-based Capsules for Microencapsulation Applications
Published on: November 9, 2016
[Entrapment of herbal extracts in biodegradable microcapsules]
Biomeditsinskaia Khimiia
|March 8, 2008
Summary
Microcapsules containing herbal extracts from Plantago major and Calendula officinalis L. were developed using layer-by-layer adsorption. Co-precipitation enhanced herbal extract entrapment, accelerating gastric ulcer treatment in rats.
Area of Science:
- Pharmacology
- Materials Science
- Biotechnology
Context:
- Development of novel drug delivery systems for herbal medicine.
- Utilizing layer-by-layer (LbL) adsorption for microcapsule fabrication.
- Investigating the potential of Plantago major and Calendula officinalis L. extracts for therapeutic applications.
Purpose:
- To prepare microcapsules encapsulating water-soluble herbal extracts (HE) from Plantago major and Calendula officinalis L.
- To compare adsorption and co-precipitation methods for HE entrapment efficiency.
- To evaluate the in vitro release kinetics of HE from microcapsules in artificial gastric juice (AGJ).
- To assess the efficacy of HE-loaded microcapsules in accelerating gastric ulcer treatment in a rat model.
Summary:
- Microcapsules were fabricated using LbL-adsorption of carrageenan and modified chitosan onto CaCO3 microparticles, followed by EDTA dissolution.
- Co-precipitation demonstrated superior entrapment of HE compared to the adsorption technique.
- In vitro release studies in AGJ were conducted to understand HE release profiles.
- The study demonstrated that HE release from these microcapsules accelerated gastric ulcer healing in rats.
Impact:
- Successful development of a microencapsulation technique for water-soluble herbal extracts.
- Demonstrated the superiority of co-precipitation for enhanced drug loading.
- Provided evidence for the therapeutic potential of Plantago major and Calendula officinalis L. extracts in gastric ulcer treatment.
- Highlights a promising approach for developing effective herbal-based gastroprotective agents.
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