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Published on: August 15, 2016
[Preparation of alpha-hydrocycholic-beta-cyclodextrin inclusion compound]
Yan-hong Bian1, Dan-yan Zhang, Qing-ping Xiong
1Department of Pharmacy, Huai'an Second Hospital, Huai'an 223002, China. zqh67@163.com
Objective:
To study the preparation of alpha-Hydrocycholic-beta-Cyclodextrin inclusion compound.
Methods:
It was studied with orthogonal design to analysis three factors of inclusion rate such as the weight ratio between HDCA and beta-Cyclodextrin, the temperature and the reaction time. Fourier transform infrared spectroscopy, scanning electron microscopy, taste and solubility test were used to identify the inclusion compound.
Results:
Stable inclusion compound was made by HDCA and beta-Cyclodextrin. The weight ratio between HDCA and beta-Cyclodextrin was the most important factor. The alpha-Hydrocycholic-beta-Cyclodextrin inclusion compound taste and the solubility were improved.
Conclusion:
The optimum preparation condition is alpha-Hydrocycholic : beta-Cyclodextrin = 8.67 : 1, the inclusion temperature is 60 degrees C and the inclusion time is 30 minutes.
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