Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Lactiplantibacillus plantarum</i> <sup>WJL</sup> ameliorates chronic kidney disease by inhibiting fibroblast growth factor 21 adaptive stress response via low protein diet.

Gut microbes·2026
Same author

Kidney dysfunction regulates gut transporters.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Supplementation with <i>Enterococcus lactis</i> (SF68) and its association with biochemical parameters and inflammatory biomarkers related to renal impairment in dogs with chronic kidney disease.

The veterinary quarterly·2026
Same author

Kidney Function Modulates Gut Microbial Metabolism.

Toxins·2026
Same author

Corrigendum to "Ceftriaxone administration reduces vascular calcification associated with experimental models of chronic kidney disease." [Biomed. Pharmacother. 197 (2026), 119131].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Ceftriaxone administration reduces vascular calcification associated with experimental models of chronic kidney disease.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026

Related Experiment Video

Updated: Jul 6, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

What is new in uremic toxicity?

Raymond Vanholder1, Steven Van Laecke, Griet Glorieux

  • 1Nephrology Section, Department of Internal Medicine, University Hospital, OK12, De Pintelaan, 185, Gent, Belgium. raymond.vanholder@ugent.be

Pediatric Nephrology (Berlin, Germany)
|March 8, 2008
PubMed
Summary

Uremic toxins, particularly those difficult to remove by dialysis, cause cardiovascular damage. Advanced dialysis methods using high-flux membranes and hemodiafiltration show improved patient outcomes.

Related Experiment Videos

Last Updated: Jul 6, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Toxicology

Background:

  • Uremic syndrome arises from the kidney's inability to excrete or metabolize compounds, leading to organ system dysfunction.
  • Accumulated uremic toxins, especially those resistant to removal by dialysis, are strongly linked to cardiovascular damage.
  • Key toxin categories include small water-soluble compounds, protein-bound substances, and larger middle molecules.

Purpose of the Study:

  • To review recent advancements in understanding uremic toxins and their impact on cardiovascular health.
  • To evaluate the efficacy of novel dialysis strategies targeting difficult-to-remove uremic toxins.
  • To correlate bench study findings on toxin removal with clinical outcomes.

Main Methods:

  • Classification of uremic toxins based on physicochemical properties influencing dialysis removal.
  • Identification of newly recognized toxic compounds and their associated effects.
  • Analysis of clinical studies employing high-flux membranes and on-line hemodiafiltration.

Main Results:

  • Several newly identified compounds (e.g., polyphosphates, p-cresylsulfate) contribute to uremic toxicity.
  • Molecules that are difficult to remove by conventional dialysis appear to exert significant toxic effects.
  • Enhanced dialysis strategies, including high-flux membranes and hemodiafiltration, demonstrate improved clinical outcomes.

Conclusions:

  • The accumulation of difficult-to-remove uremic toxins is a critical factor in cardiovascular complications.
  • Modern dialysis techniques like high-flux hemodiafiltration are effective in mitigating the effects of these toxins.
  • Clinical evidence supports the importance of targeting specific uremic toxins for better patient management.