Related Experiment Video
Updated: Jul 6, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Ictus and antiphospholipid syndrome: how much is enough?
Elena Rodríguez-Castellano1, Juan José Ríos-Blanco, Angel Robles-Marhuenda
1Servicio de Medicina Interna, Hospital Universitario La Paz, P de la Castellana, 261-28046 Madrid, Spain. elena.rodriguez.c@gmail.com
Autoimmunity
|March 8, 2008
Summary
Antiphospholipid Syndrome (APS) patients experiencing ischemic stroke while on anticoagulation require careful individual risk assessment. High-intensity anticoagulation and strict monitoring are crucial for managing recurrent thrombotic events in APS.
Area of Science:
- Neurology
- Rheumatology
- Vascular Medicine
Background:
- Antiphospholipid Syndrome (APS) is an autoimmune disorder associated with an increased risk of thrombosis.
- Ischemic stroke is a serious complication that can occur in APS patients, even during anticoagulant therapy.
- Warfarin is a common anticoagulant used in APS management, but its efficacy requires careful monitoring.
Observation:
- This case report details an APS patient who suffered an ischemic stroke despite being on anticoagulation.
- Magnetic resonance angiography (MRA) was utilized for early diagnosis of the stroke complication.
- The patient had a history of multiple thrombotic recurrences.
Findings:
- The case highlights the potential for thrombotic events like ischemic stroke in APS patients even with anticoagulation.
- Magnetic resonance angiography proved useful in the early detection of this stroke complication.
- Individual risk evaluation is paramount before initiating warfarin therapy in APS patients.
Implications:
- This case underscores the importance of high-intensity anticoagulation for APS patients with a history of recurrent thrombosis.
- Strict control and monitoring of anticoagulation therapy are essential for managing APS and preventing further thrombotic events.
- The findings emphasize the need for personalized treatment strategies in APS management, considering individual risk factors.
Related Concept Videos
01:26Transient Ischemic Attack l: Introduction
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...