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Comparison of pro B-natriuretic peptide in hypertensive patients with and without diastolic dysfunction

Yudistira P Santosa1, Anna Tjandrawati, Noormartany

  • 1Department of Internal Medicine, Faculty of Medicine Atmajaya University, Jl. Pluit Raya no. 2, Jakarta. yudipsan@yahoo.com

Acta Medica Indonesiana
|March 11, 2008
PubMed

Insights

N-terminal pro-B-type natriuretic peptide (NT-pro BNP) levels tend to be higher in hypertensive patients with diastolic dysfunction. This suggests NT-pro BNP may aid in detecting this cardiac condition.

Area of Science:

  • Cardiology
  • Biomarkers
  • Hypertension Research

Background:

  • Diastolic dysfunction is a common complication in hypertensive patients.
  • Early detection of diastolic dysfunction is crucial for timely intervention and management.
  • Current diagnostic methods may have limitations in widespread screening.

Purpose of the Study:

  • To investigate the potential of N-terminal pro-B-type natriuretic peptide (NT-pro BNP) as a biomarker for diastolic dysfunction.
  • To evaluate the correlation between NT-pro BNP levels and the presence of diastolic dysfunction in hypertensive individuals.

Main Methods:

  • A cohort of 39 hypertensive patients with normal systolic function underwent echocardiography.
  • Diastolic dysfunction was identified based on specific echocardiographic mitral flow patterns.
  • NT-pro BNP levels were measured using electrochemiluminescence immunoassay (ECLIA).

Main Results:

  • Twelve out of 39 subjects exhibited normal diastolic function.
  • NT-pro BNP levels were observed to be marginally higher in the group with diastolic dysfunction (P=0.053).
  • Baseline characteristics were comparable between groups, except for uric acid levels.

Conclusions:

  • NT-pro BNP levels show a trend towards elevation in hypertensive patients with diastolic dysfunction.
  • NT-pro BNP may serve as a potential, non-invasive indicator for diastolic dysfunction in this population.
  • Further research is warranted to confirm the diagnostic utility of NT-pro BNP for diastolic dysfunction.
Abstract

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