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Related Experiment Videos

Progressive asymmetric apraxic agraphia.

Kenneth M Heilman1, Amy Coenen, Benzi Kluger

  • 1Department of Neurology, University of Florida College of Medicine, Gainesville, FL 32610, USA. heilman@neurology.ufl.edu

Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology
|March 11, 2008
PubMed
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Three patients presented with asymmetrical apraxic agraphia (AAA), a rare early symptom in degenerative diseases. This condition involves impaired letter formation but preserved oral spelling, suggesting a deficit in spatial-movement representations.

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Apraxic agraphia (AA) is characterized by impaired letter formation despite preserved oral spelling.
  • AA is commonly linked to ideomotor apraxia, often caused by stroke, but can occur in degenerative diseases.
  • Asymmetrical apraxic agraphia (AAA) is a rare presenting feature in degenerative conditions.

Purpose of the Study:

  • To report a case series of three patients with AAA.
  • To investigate the cognitive mechanisms underlying AAA.
  • To explore the potential link between AAA and corticobasal degeneration syndrome.

Main Methods:

  • Case series of three patients presenting with AAA.
  • Assessment of oral spelling, letter formation, and ideomotor apraxia.

Related Experiment Videos

  • Cognitive testing including gesture recognition, letter imagery, and tactile number recognition (agraphesthesia).

    • Main Results:

    • Patients exhibited AAA as an early symptom, without aphasia or alexia.
    • Asymmetrical ideomotor apraxia was present in all patients.
    • Impaired performance in gesture recognition and letter imagery suggested a deficit in spatial-movement representations; asymmetrical agraphesthesia was also noted.

    Conclusions:

    • AAA may represent an early manifestation of corticobasal degeneration syndrome.
    • Findings suggest AAA is associated with deterioration of graphemic and transitive spatial-movement representations.
    • Intact movement representations are crucial for tasks like tactile number recognition, and asymmetrical agraphesthesia may relate to AAA.