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Updated: Jul 6, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

An infant with bullous pemphigoid.

António Luís Santos¹, Alberto Vieira Mota, José Ramon

¹Dermatology Department, Hospital de São João and Faculty of Medicine of Oporto, Portugal.

Dermatology Online Journal

|March 11, 2008

Summary

Bullous pemphigoid, a rare autoimmune blistering disease in infants, presented unusually on palms and soles in a 5-month-old. Early diagnosis and treatment with oral deflazacort led to a favorable outcome.

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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

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Published on: June 17, 2025

Area of Science:

Dermatology
Pediatric Autoimmunology
Immunobullous Diseases

Background:

Bullous pemphigoid (BP) is a rare autoimmune blistering disease in children.
It typically affects the elderly, with pediatric cases being exceptionally uncommon.

Observation:

A 5-month-old male infant presented with bullae localized to palms and soles.
Peripheral blood showed relative eosinophilia.
Skin biopsy revealed subepidermal blisters, eosinophilic dermal infiltrate, and collagen flame figures.

Findings:

Direct immunofluorescence confirmed linear C3c and IgG deposition at the dermal-epidermal junction.
Absence of IgA was noted.
Histopathological findings were consistent with bullous pemphigoid.

Implications:

This case highlights an unusual acral presentation of bullous pemphigoid in an infant.
Prompt diagnosis and treatment with corticosteroids can lead to favorable outcomes in pediatric bullous pemphigoid.
Further research into the specific triggers and management of infantile bullous pemphigoid is warranted.