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Updated: Jul 6, 2026

Establishing a Mouse Model of Thin Endometrium
Published on: November 1, 2024
Pathophysiologic features of "thin" endometrium
Ichiro Miwa1, Hiroshi Tamura, Akihisa Takasaki
1Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Objective:
To characterize pathophysiologic features of a "thin" endometrium.
Design:
A prospective observational study.
Setting:
University Hospital and City General Hospital.
Patient(S):
Patients with normal-thickness endometrium (Normal-Em group: endometrial thickness >or=8 mm; n = 57) and thin endometrium (Thin-Em group: endometrial thickness <8 mm; n = 17).
Main Outcome Measure(S):
Blood flow impedance of the uterine radial artery (RA) was assessed as resistance index (RI) by transvaginal color-pulsed Doppler ultrasonography. The area of glandular epithelium, the number of blood vessels, and vascular endothelial growth factor (VEGF) expression were examined in the midluteal-phase endometrium.
Result(S):
The RA-RI in the Thin-Em group was significantly higher than in the Normal-Em group throughout the menstrual cycle. Endometrial thickness was significantly correlated with RA-RI. Growth of glandular epithelium, the number of blood vessels, and VEGF expression were significantly lower in the Thin-Em group than in the Normal-Em group.
Conclusion(S):
A "thin" endometrium was characterized by high blood flow impedance of RA, poor epithelial growth, decreased VEGF expression, and poor vascular development.
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