Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple endocrine neoplasms.

Alberto Falchetti1, Francesca Marini, Ettore Luzi

  • 1Surgery Unit, Department of Clinical Physiopathology, University of Florence, 6-50139 Florence, Italy.

Best Practice & Research. Clinical Rheumatology
|March 11, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endocrine-related osteoporosis: the state of the art.

Frontiers in endocrinology·2026
Same author

Osteopetrosis: Pathogenesis, Clinical Management, and Emerging Therapies.

Current osteoporosis reports·2026
Same author

The Importance of Biochemical Screenings in the Diagnosis of Hypophosphatasia: Applications, Methodologies, and Challenges.

International journal of molecular sciences·2026
Same author

Beyond the Genome: Can Epigenetics Forecast Therapeutic Success in Graves' Disease and Thyroid Eye Disease?

International journal of molecular sciences·2026
Same author

Evolving our understanding of vitamin D, periostin levels and cardiovascular risk in the elderly: a cross sectional study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2025
Same author

Human-Mediated Dispersal Routes Structure Sahara Mustard Genomics.

Molecular ecology·2025
Same journal

The young adult with Juvenile Idiopathic Arthritis (JIA): A clinical review of transition, complications, and psychosocial management.

Best practice & research. Clinical rheumatology·2026
Same journal

Impact of fatigue on rheumatic diseases: Current perspectives.

Best practice & research. Clinical rheumatology·2026
Same journal

Pneumocystis prophylaxis in rheumatic disease.

Best practice & research. Clinical rheumatology·2026
Same journal

Cutaneous manifestations in myositis syndromes.

Best practice & research. Clinical rheumatology·2026
Same journal

Systemic sclerosis: A comprehensive systematic review of global epidemiology, sex and ethnic disparities, disease burden, and organ-specific involvement.

Best practice & research. Clinical rheumatology·2026
Same journal

Alopecia across the spectrum of rheumatic disease.

Best practice & research. Clinical rheumatology·2026
See all related articles

Multiple endocrine neoplasia (MEN1 and MEN2) are rare genetic disorders causing tumors in multiple endocrine glands. MEN1 involves parathyroid, pancreas, and pituitary tumors, while MEN2 features medullary thyroid cancer and pheochromocytoma.

Area of Science:

  • Endocrinology
  • Genetics
  • Oncology

Background:

  • Multiple endocrine neoplasia (MEN) types 1 and 2 are rare, autosomal-dominant genetic disorders.
  • These syndromes are defined by primary tumors in at least two distinct endocrine tissues.
  • MEN can manifest sporadically or as a familial condition.

Purpose of the Study:

  • To differentiate the clinical and genetic characteristics of MEN1 and MEN2.
  • To highlight the key endocrine glands affected in each MEN type.
  • To underscore the genetic basis and potential malignancy of tumors in MEN syndromes.

Main Methods:

  • Review of existing literature on MEN1 and MEN2.
  • Analysis of characteristic tumor types and genetic mutations associated with each syndrome.

Related Experiment Videos

  • Comparison of disease presentation, progression, and genetic etiology.

    • Main Results:

    • MEN1 is associated with parathyroid, gastro-entero-pancreatic, and anterior pituitary tumors, typically benign but with potential malignancy in specific cases (e.g., gastrinomas).
    • MEN2 is characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and other endocrine tumors; MTC can be fatal if not diagnosed early.
    • MEN1 results from biallelic inactivation of the MEN1 gene, whereas MEN2 is caused by activating mutations in the c-RET proto-oncogene.

    Conclusions:

    • MEN1 and MEN2 are distinct genetic disorders with characteristic tumor profiles and underlying genetic mechanisms.
    • Early diagnosis and genetic understanding are crucial for managing MEN syndromes, particularly the potentially fatal MTC in MEN2.
    • The genetic basis (MEN1 gene inactivation vs. RET proto-oncogene mutations) dictates the distinct pathologies of MEN1 and MEN2.