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Updated: Jul 6, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Current approaches to the management of early active diffuse scleroderma skin disease
Svetlana I Nihtyanova1, Christopher P Denton
1Centre for Rheumatology, Royal Free Hospital, Pond Street, London NW3 2QG, UK.
Abstract:
Skin sclerosis is a clinical hallmark of systemic sclerosis (SSc) and provides a means to classify and evaluate patients. In the diffuse cutaneous subset, skin involvement is often extensive and warrants direct therapy. Currently, broad spectrum immunosuppressive strategies are used, but more targeted specific approaches are now emerging. This article reviews the evidence for efficacy of current treatment approaches and future developments for managing skin disease in early diffuse cutaneous SSc.
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