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RAGE and RAGE ligands in cancer
Craig D Logsdon1, Maren K Fuentes, Emina H Huang
1Department of Cancer Biology, The University of Texas. Anderson Cancer Center, Unit 953, 1515 Holcombe Blvd., Houston, Texas 77030, USA. clogsdon@mdanderson.org
Current Molecular Medicine
|March 12, 2008
Summary
The receptor for advanced glycation end-products (RAGE) and its ligands promote cancer progression, metastasis, and chemoresistance. Targeting the RAGE-ligand axis offers a promising therapeutic strategy for various cancers.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- The receptor for advanced glycation end-products (RAGE) is implicated in diseases like diabetes, arthritis, and Alzheimer's.
- Emerging evidence highlights RAGE's significant role in cancer development and progression.
Purpose of the Study:
- To review the role of the RAGE-ligand axis in cancer.
- To explore the therapeutic potential of targeting this axis in cancer treatment.
Main Methods:
- Literature review of studies investigating RAGE and its ligands in cancer.
- Analysis of RAGE ligand interactions with cancer cells and the tumor microenvironment.
Main Results:
- RAGE ligands (S100/calgranulins, HMGB1) secreted by cancer cells promote proliferation, invasion, chemoresistance, and metastasis.
- RAGE ligands influence tumor microenvironment cells, fostering fibrosis, inflammation, and angiogenesis.
- The RAGE-ligand axis drives cancer-promoting effects, though ligands may have other functions.
Conclusions:
- The RAGE-ligand axis is a critical factor in cancer progression and metastasis.
- Targeting the RAGE-ligand interaction presents a viable therapeutic strategy for cancer intervention.
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