Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters01:16

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Pharmacogenetics of Phase I Enzymes: Cytochrome P450 Isozymes01:28

Pharmacogenetics of Phase I Enzymes: Cytochrome P450 Isozymes

Cytochrome P450 (CYP450) enzymes are a superfamily of heme-containing monooxygenases that play a pivotal role in Phase I drug metabolism by catalyzing oxidation and reduction reactions.These enzymes transform lipophilic xenobiotics into more hydrophilic metabolites, facilitating subsequent Phase II conjugation and eventual excretion. The CYP450 family is classified into families (e.g., CYP1–CYP3) and subfamilies (e.g., CYP2A, CYP2C), based on amino acid sequence homology.CYP450 isoenzymes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Water-free care in Dutch intensive care unit patient rooms: impact on Gram-negative bacteria detections in routine patient care.

The Journal of hospital infection·2026
Same author

Diffusion MRI correlation with p16 status and prediction for tumor progression in locally advanced head and neck cancer.

Frontiers in oncology·2024
Same author

Endoscopically removed rectal NETs: a nationwide cohort study.

International journal of colorectal disease·2020
Same author

Low Incidence of Advanced Neoplasia in Serrated Polyposis Syndrome After (Sub)total Colectomy: Results of a 5-Year International Prospective Cohort Study.

The American journal of gastroenterology·2019
Same author

Risk for Incomplete Resection after Macroscopic Radical Endoscopic Resection of T1 Colorectal Cancer: A Multicenter Cohort Study.

The American journal of gastroenterology·2017
Same author

Endoscopic resection of high-risk T1 colorectal carcinoma prior to surgical resection has no adverse effect on long-term outcomes.

Gut·2016
Same journal

Recognizing Suspected Colonic Hypercompliance in Refractory Constipation When Barostat Testing Is Unavailable-Authors' Reply.

Neurogastroenterology and motility·2026
Same journal

Accuracy of Novice Raters for Esophageal Motility Classifications Using Functional Lumen Imaging Probe Panometry.

Neurogastroenterology and motility·2026
Same journal

Letter to the Editor: "Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial".

Neurogastroenterology and motility·2026
Same journal

The Drought of Evidence for Water Intake to Manage Constipation Symptoms May Be Ending.

Neurogastroenterology and motility·2026
Same journal

L-Carnitine Improves Visceral Hypersensitivity and Colonic Hyperpermeability in a Rat Model of Irritable Bowel Syndrome.

Neurogastroenterology and motility·2026
Same journal

Letter to the Editor: "Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial".

Neurogastroenterology and motility·2026
See all related articles

Related Experiment Video

Updated: Jul 6, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
06:21

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Candidate genotypes associated with functional dyspepsia.

N van Lelyveld1, J T Linde, M Schipper

  • 1Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands. n.van.lelyveld@meandermc.nl

Neurogastroenterology and Motility
|March 12, 2008
PubMed
Summary
This summary is machine-generated.

Functional dyspepsia (FD) is linked to a genetic variant in the G-protein beta 3 subunit (GNB3) gene. This finding may help understand the causes of this common gastrointestinal disorder.

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Related Experiment Videos

Last Updated: Jul 6, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
06:21

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

  • Genetics
  • Gastroenterology
  • Molecular Biology

Background:

  • Functional gastrointestinal disorders, like functional dyspepsia (FD), are increasingly recognized to have a genetic basis.
  • Understanding the genetic factors can elucidate the underlying pathophysiological mechanisms.
  • Serotonergic signaling and G-protein-mediated signal transduction pathways are crucial for gastroduodenal sensory and motor functions.

Purpose of the Study:

  • To investigate the association between functional polymorphisms in key genes and functional dyspepsia (FD).
  • Specifically, to test the role of genes involved in serotonergic signaling and G-protein-mediated signal transduction in FD pathophysiology.
  • To identify genetic predispositions that may contribute to gastroduodenal dysfunction.

Main Methods:

  • A case-control study involving 112 FD patients from a tertiary referral center and 336 age- and gender-matched healthy controls.
  • Genotyping analysis was performed for polymorphisms in the serotonin receptor type 3A subunit (HTR3A), serotonin transporter (SERT), and G-protein beta 3 subunit (GNB3) genes.
  • Statistical analysis, including odds ratios and confidence intervals, was used to compare allele and genotype frequencies between FD patients and controls.

Main Results:

  • A significantly higher prevalence of the T allele of the GNB3 C825T polymorphism was observed in FD patients compared to healthy controls (OR = 1.60, 95% CI: 1.03-2.49, P = 0.038).
  • No significant association was found between FD and the insertion/deletion polymorphism in the SERT promoter (SERT-P) or the HTR3A C178T polymorphism.
  • The GNB3 825T allele appears to be a genetic risk factor for functional dyspepsia in this tertiary referral cohort.

Conclusions:

  • The study suggests a significant association between functional dyspepsia and the 825T allele of the GNB3 gene.
  • Increased G-protein signal transduction associated with the GNB3 825T allele may contribute to the observed gastroduodenal sensory and motor abnormalities in FD.
  • These genetic findings provide insights into the molecular basis of functional dyspepsia and potential targets for future research.