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Related Experiment Video

Updated: Jul 6, 2026

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds
08:16

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds

Published on: April 2, 2018

Tissue engineering by self-assembly of cells printed into topologically defined structures.

Karoly Jakab1, Cyrille Norotte, Brook Damon

  • 1Department of Physics, University of Missouri, Columbia, Missouri 65211, USA.

Tissue Engineering. Part A
|March 13, 2008
PubMed
Summary

Researchers developed a novel 3D bioprinting technology using multicellular spheroids (bio-ink) to create functional living tissues. This approach mimics natural self-assembly for tissue engineering and organ development.

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Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering
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Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Published on: November 25, 2011

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Last Updated: Jul 6, 2026

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds
08:16

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds

Published on: April 2, 2018

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering
08:00

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Published on: November 25, 2011

Area of Science:

  • Tissue Engineering
  • Developmental Biology
  • Bioprinting Technologies

Background:

  • Biological self-assembly principles are crucial for creating functional living tissues and organs.
  • Existing tissue engineering methods require efficient strategies for constructing complex biological structures.

Purpose of the Study:

  • To exploit cellular self-organization for building functional living structures of a defined shape.
  • To develop and model a novel bioprinting technology for creating three-dimensional tissue constructs.

Main Methods:

  • Utilizing multicellular spheroids as bio-ink particles within a biocompatible bio-paper environment.
  • Employing a three-dimensional bio-printer for precise placement of bio-ink particles.
  • Modeling the postprinting fusion process of bio-ink particles for tissue formation.

Main Results:

  • Successfully printed extended cellular structures of various shapes using the novel bioprinting technology.
  • Demonstrated the formation of synchronously beating cardiac tissue blocks from embryonic cardiac and endothelial cells.
  • Observed early vascularization with endothelial cells forming vessel-like conduits within the printed constructs.

Conclusions:

  • The developed bioprinting technology effectively mimics early morphogenesis through cell self-assembly.
  • Postprinting fusion of bio-ink particles enables the creation of functional, vascularized three-dimensional tissue constructs.
  • This approach holds significant potential for advancing tissue engineering and regenerative medicine.