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Updated: Jul 6, 2026
Lethality Bioassay Using Artemia salina L.
Published on: October 11, 2022
Biologically active tetralones from New Caledonian Zygogynum spp
Noureddine Allouche1, Barbara Morleo, Odile Thoison
1Faculté des Sciences de Sfax, B.P. 802, 3018 Sfax, Tunisia.
Abstract:
Bioassay guided purification of the ethyl acetate extracts of the bark and leaves of five New Caledonian Zygogynum species (Winteraceae) led to the isolation and characterization of four phenyl-3-tetralones (3,4-dihydronaphthalen-1(2H)-one). Their structures were determined by various NMR techniques and chemical studies. The absolute configuration of the compounds was established by circular dichroism. The compounds showed binding affinity for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and significant inhibitory activity against KB cancer cell line.
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