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Total synthesis of (+/-)-mersicarpine
Jakob Magolan1, Cheryl A Carson, Michael A Kerr
1Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7.
Abstract:
The first total synthesis of the indole alkaloid mersicarpine is reported. Key steps include a beta-dicarbonyl radical cyclization, as well as an oxidation of the benzopyrrole moiety to establish the masked 1,2-dicarbonyl functionality. An X-ray crystal structure and discussion of the 1H NMR behavior of the natural product are also presented.
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