Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mass media competition and alternative ordering in social dynamics.

Physical review. E·2024
Same author

COVIDGR Dataset and COVID-SDNet Methodology for Predicting COVID-19 Based on Chest X-Ray Images.

IEEE journal of biomedical and health informatics·2020
Same author

Reduced work/academic performance and quality of life in patients with allergic rhinitis and impact of allergen immunotherapy.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2016
Same author

[It is possible to humanize the semen samples collection respecting privacy of subjects? A preliminary report].

Revista de calidad asistencial : organo de la Sociedad Espanola de Calidad Asistencial·2016
Same author

The improved biological response of shark tooth bioapatites in a comparative in vitro study with synthetic and bovine bone grafts.

Biomedical materials (Bristol, England)·2016
Same author

Cost-Effectiveness of Ipilimumab for Previously Untreated Patients with Advanced Metastatic Melanoma in Spain.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016

Related Experiment Video

Updated: Jul 6, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

[Our experience in primary hyperaldosteronism].

S Gallego1, A Covarsí, J Luengo

  • 1Unidad de Hipertension Arterial, Caceres, Espana.

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|March 14, 2008
PubMed
Summary

Primary hyperaldosteronism (PHA) predominantly affects men and often presents as persistent hypertension. Surgery for adenomas improves blood pressure control and reduces cardiovascular risks.

More Related Videos

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Related Experiment Videos

Last Updated: Jul 6, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Area of Science:

  • Nephrology
  • Endocrinology
  • Hypertension Research

Context:

  • Primary hyperaldosteronism (PHA) is a significant cause of secondary hypertension.
  • Understanding PHA's clinical presentation and treatment outcomes is crucial for patient management.
  • This study focuses on PHA cases managed in an external nephrology consultation setting.

Purpose:

  • To analyze the clinical characteristics, diagnosis, and treatment of primary hyperaldosteronism.
  • To investigate the prevalence and presentation of PHA in a specific patient cohort.
  • To evaluate the effectiveness of surgical and medical interventions for PHA.

Summary:

  • A retrospective study analyzed 35 patients diagnosed with PHA between 1981-2005.
  • The cohort showed a male predominance (82%) and common presentation of persistent hypertension.
  • Adenomas and hyperplasia occurred with similar frequency; surgery improved hypertension control with reduced medication and aldosterone levels.

Impact:

  • Findings suggest a male predominance in PHA, contrary to some literature.
  • Surgical treatment of adenomas leads to better blood pressure control and reduced cardiovascular toxicity.
  • This research contributes to optimizing diagnostic and therapeutic strategies for primary hyperaldosteronism.