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Updated: Jul 6, 2026
05:48
Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
[Systemic AA amyloidosis induced by benign neoplasms].
O Bestard Matamoros1, R Poveda Monje, M Ibernon Vilaró
1Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona. 35830obm@comb.es
Summary
AA amyloidosis can result from benign neoplasms, not just chronic inflammation. Early diagnosis and treatment of these tumors may lead to regression of AA amyloidosis.
Area of Science:
- Nephrology
- Oncology
- Immunology
Background:
- Amyloidosis is a systemic disorder involving the deposition of toxic protein aggregates.
- AA amyloidosis, a common type, results from serum amyloid A (SAA) protein fragments and often complicates chronic inflammatory diseases.
- While less common, benign neoplasms can also lead to AA amyloidosis.
Observation:
- Two cases of AA amyloidosis secondary to benign neoplasms are presented.
- Case 1: A hepatic adenoma led to AA amyloidosis with nephrotic syndrome, resulting in renal failure and subsequent kidney transplantation.
- Case 2: Castleman's disease caused AA amyloidosis and nephrotic syndrome, leading to renal failure and kidney transplantation.
Findings:
- Benign tumors, such as hepatic adenoma and Castleman's disease, can be etiological causes of AA amyloidosis.
- AA amyloidosis presentation can include primary kidney involvement, such as nephrotic syndrome.
- Despite treatment and transplantation, progressive renal failure can occur.
Implications:
- Benign neoplasms should be considered as potential causes of AA amyloidosis.
- Early diagnosis and treatment of associated neoplasms may facilitate regression of AA amyloidosis.
- This highlights the importance of a comprehensive etiological investigation in amyloidosis cases.
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