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Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

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Related Experiment Video

Updated: Jul 6, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
09:49

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Published on: July 5, 2019

Oncogenomics.

Virendra S Gomase1, Somnath Tagore, Karbhari V Kale

  • 1Department of Bioinformatics, Dr. D.Y. Patil Institute for Biotechnology and Bioinformatics, Padmashree Dr. D.Y. Patil University, Plot No-50, Sector-15, CBD Belapur, Navi Mumbai, 400614, India. virusgene1@yahoo.co.in

Current Drug Metabolism
|March 14, 2008
PubMed
Summary
This summary is machine-generated.

Oncogenomics advances early cancer diagnosis and personalized treatments by identifying new drug targets. This field integrates molecular profiling, drug development, and clinical trials, accelerating cancer research and patient care.

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Last Updated: Jul 6, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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Published on: July 5, 2019

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Area of Science:

  • Genomics and Proteomics
  • Cancer Research
  • Translational Medicine

Background:

  • Genomics and proteomics advancements offer new possibilities for early cancer diagnosis, prognosis, and predisposition detection.
  • Oncogenomics has identified novel drug targets for genotype-specific cancer therapies.
  • The increasing need for patient stratification by genotype complicates clinical trials for targeted drugs.

Purpose of the Study:

  • To highlight the progression and impact of oncogenomics in cancer research.
  • To discuss the integration of molecular profiling, drug development, and clinical trials.
  • To cover emerging issues in cancer genomics and targeted therapeutics.

Main Methods:

  • Molecular profiling of tumors
  • Development of genotype-specific drugs
  • Validation of drug targets
  • Conducting clinical trials
  • Array-based diagnostics
  • Pharmacogenomics and pharmacoproteomics

Main Results:

  • Identification of new drug targets for personalized cancer treatments.
  • Strategies for validating targets and developing novel therapeutics.
  • Progress from molecular profiling to clinical application.

Conclusions:

  • Oncogenomics is crucial for advancing personalized cancer medicine.
  • The field encompasses diagnostics, therapeutics, and ethical considerations.
  • Continued research in oncogenomics promises improved patient outcomes.