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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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Related Experiment Video

Updated: Jul 6, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Proteomics: technologies for protein analysis.

Virendra S Gomase1, Karbhari V Kale, Somnath Tagore

  • 1Department of Bioinformatics, Dr. D. Y. Patil Institute for Biotechnology and Bioinformatics, Padmashree Dr. D. Y. Patil University, Plot No-50, Sector-15, CBD Belapur, Navi Mumbai, 400614, India. virusgene1@yahoo.co.in

Current Drug Metabolism
|March 14, 2008
PubMed
Summary
This summary is machine-generated.

Proteomics technologies identify protein drug targets, aiding drug development. This review compares key proteomics strategies and bioinformatics tools for effective target validation and protein analysis.

More Related Videos

TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis
07:44

TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis

Published on: June 8, 2020

Related Experiment Videos

Last Updated: Jul 6, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis
07:44

TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis

Published on: June 8, 2020

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • Proteomics technologies generate numerous potential drug targets, leading to bottlenecks in drug development.
  • Effective target validation is crucial for new drug development, with proteomics playing a significant role.
  • Identifying protein drug targets within cells presents a major challenge in modern drug discovery.

Purpose of the Study:

  • To review key technologies used in proteomics strategies for drug target identification.
  • To compare different proteomics techniques for protein separation and detection.
  • To highlight the application of bioinformatics in supporting proteomics-based target validation.

Main Methods:

  • Comparative analysis of various proteomics technologies.
  • Discussion of protein separation and detection techniques.
  • Integration of bioinformatics tools for data analysis and interpretation.

Main Results:

  • Proteomics technologies are vital tools for screening the proteome and identifying potential drug targets.
  • Comparison of technologies aids in selecting appropriate methods for specific research needs.
  • Bioinformatics analysis provides comprehensive molecular descriptions and predictive functional information.

Conclusions:

  • Proteomics technologies are essential for advancing drug discovery and target validation.
  • Further improvements in proteomics will enhance its contribution alongside genomics and chemical technologies.
  • The synergy between proteomics and bioinformatics offers powerful solutions for protein analysis and drug development.