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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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Epigenomics.

Virendra S Gomase1, Somnath Tagore

  • 1Department of Bioinformatics, Dr. D.Y. Patil Institute for Biotechnology and Bioinformatics, Padmashree Dr. D.Y. Patil University, Plot No-50, Sector-15, CBD Belapur, Navi Mumbai, 400614, India. virusgene1@yahoo.co.in

Current Drug Metabolism
|March 14, 2008
PubMed
Summary
This summary is machine-generated.

Epigenomics studies how gene activity changes without altering DNA sequence, offering insights into major psychosis and environmental interactions. This research may lead to novel diagnostics and therapies for conditions like schizophrenia and bipolar disorder.

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Area of Science:

  • * Epigenomics: The study of gene activity alterations without DNA sequence changes.
  • * Focus on chromatin structure, DNA methylation, and histone modifications.

Background:

  • * Epigenetic modifications can be transmitted to daughter cells.
  • * Understanding gene regulation changes in major psychosis is crucial.
  • * Investigating why genetic predispositions vary in conditions like schizophrenia and bipolar disorder.

Purpose of the Study:

  • * To elucidate the molecular mechanisms underlying major psychosis.
  • * To understand gene-environment interactions in the context of epigenomics.
  • * To explore the role of epigenetics in differential disease susceptibility.

Main Methods:

  • * Analysis of chromatin structure and higher-order folding.
  • * Assessment of DNA methylation patterns.
  • * Examination of covalent histone tail modifications.

Main Results:

  • * Identified epigenetic alterations associated with major psychosis.
  • * Elucidated mechanisms of gene-environment interactions.
  • * Provided insights into variable genetic predisposition to psychiatric disorders.

Conclusions:

  • * Epigenomics offers a framework for understanding complex psychiatric disorders.
  • * Findings may pave the way for new diagnostic tools.
  • * Potential for developing targeted epigenetic therapies.