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Updated: Jul 6, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of
David G Bowen1, Naglaa H Shoukry, Arash Grakoui
1Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, 700 Childrens Dr., Columbus, OH 43205, USA.
Abstract:
The inhibitory receptor programmed death-1 (PD-1) is present on CD8(+) T cells in chronic hepatitis C virus (HCV), but expression patterns in spontaneously resolving infections are incompletely characterized. Here we report that PD-1 was usually absent on memory CD8(+) T cells from chimpanzees with resolved infections, but sustained low-level expression was sometimes observed in the absence of apparent virus replication. PD-1-positive memory T cells expanded and displayed antiviral activity upon reinfection with HCV, indicating conserved function. This animal model should facilitate studies of whether PD-1 differentially influences effector and memory T-cell function in resolved versus persistent human infections.
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