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Related Concept Videos

Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group with both...
Five-Membered Heterocyclic Aromatic Compounds: Overview01:13

Five-Membered Heterocyclic Aromatic Compounds: Overview

Heterocyclic aromatic compounds are cyclic compounds that are aromatic and have one or more heteroatoms—atoms other than carbon, in the ring. Depending upon the number of atoms present in the ring, they can be either five or six-membered. Examples of five-membered heterocyclic aromatic compounds include pyrrole, furan, thiophene, and imidazole. Pyrrole consists of one nitrogen atom having one lone pair of electrons. Furan and thiophene have one oxygen and one sulfur heteroatom, respectively.

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Related Experiment Video

Updated: Jul 6, 2026

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
05:32

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines

Published on: May 12, 2023

Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition.

Zoë A E Waller1, Pravin S Shirude, Raphaël Rodriguez

  • 1The University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.

Chemical Communications (Cambridge, England)
|March 14, 2008
PubMed
Summary

Triarylpyridines are effective G-quadruplex ligands, showing high selectivity for these structures over duplex DNA. They demonstrate promising discrimination between different types of intramolecular quadruplexes.

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Last Updated: Jul 6, 2026

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

Area of Science:

  • Medicinal Chemistry
  • Molecular Biology
  • Biochemistry

Background:

  • G-quadruplexes are non-canonical DNA structures implicated in various biological processes.
  • Targeting G-quadruplexes is a promising strategy for therapeutic intervention.
  • Developing selective ligands for G-quadruplexes is crucial for minimizing off-target effects.

Purpose of the Study:

  • To investigate the potential of triarylpyridines as selective G-quadruplex ligands.
  • To evaluate the discrimination of triarylpyridines between G-quadruplex and duplex DNA.
  • To assess the selectivity of triarylpyridines among different intramolecular G-quadruplex topologies.

Main Methods:

  • Synthesis and characterization of novel triarylpyridine compounds.
  • Biophysical assays (e.g., fluorescence spectroscopy, surface plasmon resonance) to assess DNA binding.
  • Electrophoretic mobility shift assays (EMSAs) to evaluate selectivity.
  • Computational modeling to understand ligand-quadruplex interactions.

Main Results:

  • Triarylpyridines exhibit potent binding to G-quadruplex DNA.
  • These ligands demonstrate high selectivity against double-stranded (duplex) DNA.
  • Promising selectivity was observed between various intramolecular G-quadruplex structures.

Conclusions:

  • Triarylpyridines represent a promising class of G-quadruplex ligands.
  • Their high selectivity profile warrants further investigation for therapeutic applications.
  • These compounds could serve as valuable tools for G-quadruplex research.