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Updated: Jul 6, 2026

Stochastic Noise Application for the Assessment of Medial Vestibular Nucleus Neuron Sensitivity In Vitro
Published on: August 28, 2019
Effects of intrinsic and extrinsic noise can accelerate juxtacrine pattern formation
1Advanced Computational Modelling Centre, University of Queensland, Brisbane, QLD, 4072, Australia.
Abstract:
Epithelial pattern formation is an important phenomenon that, for example, has roles in embryogenesis, development and wound-healing. The ligand Epithelial Growth Factor (EGF) and its receptor EGF-R, constitute a system that forms lateral induction patterns by juxtacrine signalling-binding of membrane-bound ligands to receptors on neighbouring cells. Owen et al. developed a generic ordinary differential equation model of juxtacrine lateral induction that exhibits stable patterning under some conditions. The model predicts relatively slow pattern formation. We examine here the effects of both intrinsic and extrinsic cellular noise arising from the stochastic treatment of this model, and show that this noise could have an accelerating effect on the patterning process.
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