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Cervical cancer screening program integrating Pap smear and HPV DNA testing: a population-based study.
Angel Chao1, Kuang-Hung Hsu, Chyong-Huey Lai
1Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.
International Journal of Cancer
|March 15, 2008
Summary
Adding HPV testing to Papanicolaou (Pap) smears improved cervical cancer screening sensitivity by 15.3% in women aged 30+ in Taiwan. Further follow-up is needed to assess the long-term benefits of this combined strategy.
Area of Science:
- Gynecology
- Oncology
- Epidemiology
Background:
- Cervical cancer screening relies on Papanicolaou (Pap) smears.
- Human papillomavirus (HPV) testing offers a complementary approach.
- Understanding HPV prevalence and genotype distribution is crucial for screening strategies.
Purpose of the Study:
- To evaluate the added value of HPV testing to Pap smears.
- To determine HPV prevalence and genotype distribution in Taiwanese women.
- To analyze factors associated with HPV prevalence and abnormal Pap smears.
Main Methods:
- A population-based cohort study involving 10,014 women aged 30+ in Taoyuan, Taiwan.
- Participants underwent both Pap smear and HPV testing.
- Referral for colposcopy was based on specific Pap results or HPV positivity with normal cytology.
Main Results:
- Overall HPV prevalence was 10.8%, with HPV-52, -18, and -58 being the most common genotypes.
- HPV prevalence correlated positively with older age, postmenopausal status, and oral contraceptive use.
- The combined HPV and Pap strategy improved sensitivity by 15.3% for detecting cervical intraepithelial neoplasia (CIN) 2.
Conclusions:
- Co-testing with HPV and Pap smears enhances cervical cancer screening sensitivity.
- HPV prevalence is influenced by various demographic and lifestyle factors in this population.
- Longer-term follow-up is necessary to fully assess the benefits of integrating HPV testing into routine cervical cancer screening.
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