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Guest aggregation within poly(L-lactic acid)/pluronic P104 thin films.

Jordan M Steves¹, Loraine T Tan, Joseph A Gardella

¹Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.

Applied Spectroscopy

|March 15, 2008

Summary

This study shows that Rhodamine 6G (R6G) aggregation in biodegradable polymer films increases with higher R6G and Pluronic P104 concentrations. This offers a method for analyzing drug distribution within polymer formulations.

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Area of Science:

Materials Science
Polymer Chemistry
Spectroscopy

Background:

Biodegradable polymers like poly(L-lactic acid) (PLLA) are crucial for drug delivery systems.
Understanding drug aggregation within these polymers is essential for controlling release profiles.
Rhodamine 6G (R6G) serves as a model fluorescent dye to study molecular behavior.

Purpose of the Study:

To investigate the aggregation behavior of Rhodamine 6G (R6G) in poly(L-lactic acid) (PLLA) and Pluronic P104 blend films.
To determine the influence of R6G concentration and Pluronic P104 content on R6G aggregation.
To establish a spectroscopic method for assessing drug distribution in biodegradable polymer matrices.

Main Methods:

Fabrication of R6G-doped PLLA/Pluronic P104 thin films using spin-casting.

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Characterization using ultraviolet-visible (UV-Vis) spectroscopy.

Analysis of fluorescence properties via steady-state and time-resolved fluorescence spectroscopy.

Main Results:

Rhodamine 6G (R6G) aggregation was observed to increase with higher concentrations of R6G within the polymer films.
Increased loading of Pluronic P104 also correlated with enhanced R6G aggregation.
Spectroscopic data indicated changes in R6G's photophysical properties due to aggregation.

Conclusions:

The concentration of R6G and the amount of Pluronic P104 significantly affect R6G aggregation in PLLA films.
Spectroscopic techniques provide a viable method for studying the distribution of monomers and aggregates of substances within biodegradable polymers.
This research contributes to the development of advanced drug delivery systems by enabling better control over drug formulation and release.