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Related Experiment Video

Updated: Jul 6, 2026

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

Low oxygen stimulates the immune system.

J S Maltzman¹, V H Haase

¹Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. maltz@mail.med.upenn.edu

Kidney International

|March 15, 2008

Summary

Hypoxia, or low oxygen levels, triggers molecular pathways that control cell growth. This study shows hypoxia drives dendritic cell maturation, linking low oxygen to immune system activation in the kidney.

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An Optimized Protocol to Analyze Glycolysis and Mitochondrial Respiration in Lymphocytes

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Published on: November 21, 2016

Area of Science:

Immunology
Cell Biology
Physiology

Background:

Tissue oxygen levels are critical regulators of cellular functions, including proliferation and differentiation.
The role of oxygen-dependent signaling in the immune system remains largely unexplored.

Purpose of the Study:

To investigate the functional role of oxygen signaling in immune cells.
To elucidate the mechanistic link between hypoxia and immune system activation.

Main Methods:

Investigated the effect of hypoxia on dendritic cell maturation.
Analyzed molecular signaling pathways involved in oxygen sensing.

Main Results:

Demonstrated that hypoxia induces dendritic cell maturation.
Identified a novel connection between hypoxia/ischemia and immune system activation within the kidney.

Conclusions:

Hypoxia plays a significant role in regulating immune cell function.
Provides a new understanding of how oxygen levels impact kidney immunity.