Related Experiment Videos
Amphotericin B stimulates secretion of beta-hexosaminidase from mouse adherent spleen cells
T Beccari1, R Mazzolla, E Constanzi
1Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università di Perugia, Italy.
Biochemistry International
|May 1, 1991
Abstract:
Secretion of the lysosomal enzyme hexosaminidase is induced by amphotericin B in mouse spleen adherent cells that show a significant increase in their candidacidal activity. The stimulation of beta-hexosaminidase is both time and dose dependent. Amphotericin B treatment did not change hexosaminidase expression that is represented mainly by "A-type" hexosaminidase in macrophages, on the basis of its biochemical properties.