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Updated: Jul 6, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
On-virus construction of polyvalent glycan ligands for cell-surface receptors
Eiton Kaltgrad1, Mary K O'Reilly, Liang Liao
1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Abstract:
Glycans arrayed on the exterior of virus particles were used as substrates for glycosyltransferase reactions to build di- and trisaccharides from the virus surface. The resulting particles exhibited tight and specific associations with cognate receptors on beads and cells, in one example defeating in cis cell-surface interactions in a manner characteristic of polyvalent binding. Combined with the ability of viruses to provide structurally well-defined attachment points, the methodology provides a convenient and powerful way to prepare complex carbohydrate ligands for clustered receptors.
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