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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...

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Related Experiment Video

Updated: Jul 6, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

[Staphylococcal scalded skin syndrome].

A P Nso Roca1, F Baquero-Artigao, M J García-Miguel

  • 1Unidad de Enfermedades Infecciosas, Hospital Universitario Infantil La Paz, Madrid, Spain. ananso@yahoo.es

Anales De Pediatria (Barcelona, Spain : 2003)
|March 18, 2008
PubMed
Summary

Staphylococcal scalded skin syndrome appears more common recently. This condition requires prompt recognition of specific skin and eye symptoms in children for effective treatment.

Related Experiment Videos

Last Updated: Jul 6, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Area of Science:

  • Pediatric Dermatology
  • Infectious Diseases
  • Epidemiology

Context:

  • Staphylococcal scalded skin syndrome (SSSS) is a severe skin condition caused by Staphylococcus aureus exfoliative toxins.
  • Limited epidemiological data exist for SSSS in many regions.
  • Understanding disease patterns is crucial for early diagnosis and management.

Purpose:

  • To describe the epidemiology and clinical features of SSSS in a pediatric population.
  • To analyze trends in SSSS incidence over a ten-year period.
  • To evaluate diagnostic and treatment approaches for SSSS.

Summary:

  • A ten-year observational study identified 26 pediatric cases of SSSS.
  • Erythroderma, blisters, and perioral/conjunctival lesions were key clinical signs.
  • Staphylococcus aureus was identified in most cases, with strains sensitive to cloxacillin, which proved effective in treatment.

Impact:

  • Suggests an increasing incidence of SSSS in recent years.
  • Highlights the importance of clinical suspicion for diagnosis, as lab markers were not significantly elevated.
  • Confirms cloxacillin as an effective treatment, leading to recovery without sequelae.